Name: Quick-Baked Spinach Artichoke Chicken Casserole Recipe
Prep time: 10 min
Cook time: PT-491673H32M45S
Total time: PT-491673H32M45S
Cuisine: American
Ingredients: 2 lbs boneless, skinless chicken breasts; 4 oz cream cheese, softened; 1/2 cup mayonnaise; 1 tbsp dijon mustard; 2 cloves garlic, minced; 1/2 tsp kosher salt; 1/2 tsp black pepper; 1/2 cup freshly grated parmesan cheese, divided; 2/3 cup shredded mozzarella cheese, divided; 8 oz marinated artichoke hearts, drained; 3 cups fresh spinach (about 4 oz)

Jump to Recipe· 4.4 from 2 reviews

If you’re craving a comforting dish that feels indulgent yet comes together with ease, this Quick-Baked Spinach Artichoke Chicken Casserole Recipe is an absolute winner. Imagine tender, juicy chicken breasts smothered in a rich and creamy blend of cream cheese, mayonnaise, garlic, and tangy Dijon mustard, all mingling with fresh spinach and marinated artichokes, then baked until bubbly and golden on top. It’s like your favorite spinach artichoke dip transformed into a hearty, satisfying meal that’s perfect for weeknights or a cozy weekend dinner. This casserole not only bursts with flavor but is also a breeze to prepare, making it a reliable go-to when you want to wow without the hassle.

Ingredients You’ll Need

In a white bowl, there is a creamy pasta salad with three main layers: the pasta layer, the spinach leaves, and the thick white sauce. The pasta pieces are light yellow and shell-shaped, mixed evenly with green spinach leaves that have smooth, curved edges. The whole mix is covered in a rich, creamy white sauce with small black pepper flecks, giving it a textured look. There is a silver spoon partly inside the bowl at the right side, mixing the salad. The bowl is placed on a white marbled surface. photo taken with an iphone --ar 4:5 --v 7

Every ingredient in this Quick-Baked Spinach Artichoke Chicken Casserole Recipe plays a vital role, from creating layers of creamy texture to adding punchy flavor and vibrant color. These simple essentials come together beautifully to elevate a classic comfort food into something truly special.

2 lbs chicken breast (boneless and skinless): The star protein that stays juicy and tender throughout baking.
4 oz cream cheese (softened): Adds luscious creaminess and helps bind the casserole.
1/2 cup mayonnaise: Boosts richness and keeps the mixture smooth.
1 tbsp Dijon mustard: Provides a gentle tang and depth of flavor.
2 cloves garlic (minced): Brings a savory aromatic punch.
1/2 cup freshly grated Parmesan cheese: Offers a sharp, salty finish that crisps beautifully.
2/3 cup mozzarella cheese: Melts into gooey, comforting goodness.
1/2 tsp kosher salt: Enhances all the flavors perfectly.
1/2 tsp black pepper: Adds subtle heat and complexity.
8 oz marinated artichokes (drained): Lends a bright, slightly tangy note and tender texture.
3 cups fresh spinach (or 4 oz): Adds vibrant color and a mild, earthy flavor.

How to Make Quick-Baked Spinach Artichoke Chicken Casserole Recipe

Step 1: Prep the Chicken Base

Start by preheating your oven to 375 degrees F. Lightly grease a 9×13 casserole dish to prevent sticking, then nestle your boneless, skinless chicken breasts in the dish in a single layer. This forms the hearty foundation of the casserole, ensuring each bite is packed with tender chicken.

Step 2: Whip Up the Creamy Mixture

In a large bowl, combine the softened cream cheese, mayonnaise, Dijon mustard, minced garlic, kosher salt, and black pepper using an electric mixer or whisk until smooth and creamy. This mixture is the magic binding agent that imparts rich flavor and luscious texture to the casserole.

Step 3: Add Cheeses, Artichokes, and Spinach

Stir in most of the Parmesan and mozzarella cheeses into your creamy base, reserving a small handful to sprinkle on top later. Gently fold in the drained marinated artichokes and fresh spinach until evenly distributed. These ingredients bring freshness and a slight tang that perfectly balances the richness.

Step 4: Assemble and Bake

Carefully spoon the creamy spinach and artichoke mixture over the chicken breasts, spreading it out into an even layer. Sprinkle the remaining Parmesan and mozzarella on top for a delectably cheesy crust. Bake uncovered for 30 to 35 minutes or until the chicken is fully cooked and the cheese is golden and bubbly. For an extra crisp finish, you can increase the oven temperature to 425 degrees F after 25 minutes and bake an additional 5 to 10 minutes, watching carefully to avoid burning.

Step 5: Serve and Enjoy

Once baked to perfection, this casserole is ready to delight your taste buds. Let it rest a few minutes for easier serving, then dive in alongside your favorite sides.

How to Serve Quick-Baked Spinach Artichoke Chicken Casserole Recipe

On a white plate, there are two main parts: on the left, a piece of food with a creamy white sauce covered in melted cheese with green herbs and small slices of artichoke on top, slightly browned and textured; on the right, a mound of white rice with small green herb leaves sprinkled over it and some pepper visible; the plate sits on a white marbled surface with a silver fork on the left side and two clear glasses of water in the background, along with a blue and white striped cloth nearby, photo taken with an iphone --ar 4:5 --v 7

Garnishes

A sprinkle of freshly chopped parsley or basil brightens up the richness and adds a pop of fresh green color, making every serving look as good as it tastes. A light drizzle of extra virgin olive oil can also enhance the overall flavor with a subtle fruity note.

Side Dishes

This casserole pairs wonderfully with warm, fluffy rice or low-carb cauliflower rice for a nutritious balance. You can also serve it alongside buttered pasta or garlic bread to soak up all those creamy, cheesy juices. For a crisp contrast, a simple mixed green salad with a tangy vinaigrette is a smart choice.

Creative Ways to Present

Try serving individual portions in small oven-safe ramekins for a charming personal touch, perfect for dinner parties or family meals. Alternatively, layering this casserole over polenta makes for an elegant yet comforting plate that’s sure to impress anyone at your table.

Make Ahead and Storage

Storing Leftovers

Any leftovers from your Quick-Baked Spinach Artichoke Chicken Casserole Recipe can be stored in an airtight container in the refrigerator for up to 3 days. The flavors actually deepen after a day, making for a delicious next-day meal that’s perfect reheated.

Freezing

If you want to keep this dish longer, it freezes beautifully. Transfer cooled leftovers into freezer-safe containers or heavy-duty freezer bags and store for up to 2 months. When ready to eat, thaw overnight in the fridge before reheating.

Reheating

To reheat, place the casserole or portions in an oven-safe dish and warm at 350 degrees F for 15-20 minutes until heated through. Cover loosely with foil to preserve moisture, uncover in the last 5 minutes to re-crisp the cheese topping. Microwaving is quick but may soften the crust slightly.

FAQs

Can I use frozen spinach instead of fresh?

Yes! Just make sure to thoroughly thaw and drain the frozen spinach to remove excess water, so your casserole doesn’t become soggy. Fresh spinach adds better texture and color, but frozen works well in a pinch.

Is it possible to use other cheeses?

Absolutely. Gruyère or provolone are great alternatives that melt beautifully and add unique flavor dimensions. Just keep the total cheese quantity similar to maintain creaminess and balance.

Can I prepare this casserole ahead of time?

Definitely! You can assemble the casserole a few hours before baking and keep it refrigerated. When ready, simply bake as directed, adding a few extra minutes if it’s cold from the fridge.

What if I don’t have marinated artichokes?

Fresh or canned artichokes can substitute, but marinated ones add a delightful tang and depth thanks to the seasoning. If using fresh or canned, consider adding a splash of lemon juice or a pinch of herbs to the mixture.

Is this recipe kid-friendly?

Yes, most kids will enjoy the creamy, cheesy flavors and tender chicken. You can reduce the garlic or Dijon mustard slightly if your little ones prefer milder tastes.

Final Thoughts

This Quick-Baked Spinach Artichoke Chicken Casserole Recipe is a reliable crowd-pleaser that combines ease with incredible taste. Whether it’s a busy weeknight or a relaxed weekend meal, this casserole delivers comfort and flavor in one cheesy, creamy package. Give it a try and watch it become your new favorite dish to share with family and friends!